RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
| PAG Title | RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
| PAG ID | PEX001513 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 384 |
| Information Content | Rich |
| Other IDs | PF00076 |
| Base PAG ID | PEX001513 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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